Endocrine Abstracts

Introduction: In transsexualism, cross-sex hormone treatment (CHT) both improves and impairs several surrogate cardiovascular risk markers in female to male (FtoM). Few randomized trials on CHT with long follow-up and control group are available, and present evidence is inconsistent. We here assess changes in metabolic and cardiovascular risk after 12 months CHT compared with biological sex in FtoM GID.Methods: Prospective observational study, including ...

Background: Several ultrasound (US) scoring systems have been proposed to provide rules for standardizing risk stratification of thyroid nodules and to select which nodules should have a fine needle aspiration (FNA) biopsy performed. TI-RADS classification is one of the most used in the daily practise. Recently, EU-TIRADS scoring system has been published to simplify the evaluation of thyroid nodules and to integrate previous classifications into a single system. We aimed to c...

Introduction: Chronic hypercortisolism is marked by an increased cardiovascular risk pattern. Atherosclerosis is a chronic inflammation that involves both innate and adaptive immunity. Glucocorticoids (GC) are immune-suppressors and adrenocorticotrophic hormone (ACTH) possesses immune-modulatory activities. GC and ACTH may act in atherothrombotic inflammatory pathways.Aim: To analyze the immune cells pattern in endogenous Cushing syndrome (CS) in order t...

Exosomes are nano-sized vesicles secreted by the cells in the exatracellular fluids representing a novel way of intracellular communication. Exosomes secreted from blood cells like monocytes and platetes have been reported to be checkpoints involved in haemostatic and thrombotic response. Glucocorticoids are inducing a profound alteration of blood cells homeostasis with atherothrombotic, bleeding and immune response alterations. Hereby we quantified for the first time circulat...

Introduction: Waist circumference is a validated tool to measure obesity-associated cardiovascular risk factor. However it does not differentiate between superficial and visceral abdominal fat. Ultrasonography has many advantages over TC/DEXA in abdominal fat assessment, specially imaging pre-peritoneal, omental and retroperitoneal fat. Our aims were to validate the diagnostic technique and to observe correlations between different abdominal fat layers with clinical and analyt...

IntroductionDiffuse optic techniques exploit the capability of penetration of near infrared light to investigate the properties and physiology of tissues. Based on this property, the LUCA device (Laser and Ultrasound Co-Analyzer of Thyroid nodules), a multi-modal device that combines two different diffuse optical techniques – time resolved and diffuse correlation spectroscopies – with ultrasound in the same transducer, has been developed with t...

Objectives: Most transgender persons (0.3-0.5% of total population) are under gender-affirming hormone therapy (GAHT). Several studies have reported an increased morbimortality due to cardiovascular events (CVE), infectious disease and suicide. However, these studies were made on small populations and short follow up. We evaluated the changes on anthropometric variables, risk factors for cardiovascular diseases (CVD) and CVE at 5 and 10 years of follow up in a transgender popu...

Background: The most common tool to test malignancy in the study of thyroid nodules (TN) is ultrasound and fine needle aspiration biopsy (FNAB). However, the sensitivity and specificity of the methods and the effectiveness in thyroid cancer are limited; therefore new methods to study thyroid nodules are required. In this way our goal is to introduce hybrid diffuse optical instruments that are capable to measure and discriminate altered microvascular blood flow, blood volume an...